FACTORS RELATED WITH HEPATITIS C VIRUS PREVALENCE INFECTION AMONG SEXUAL PARTNERS OF HUMAN IMMUNODEFICIENCY VIRUS AND HEPATITIS C VIRUS COINFECTED PATIENTS.

Kurniawati Sri Agustini, THESIS, Jakarta, Medical School, University of Indonesia, Jakarta 2008.

Background
Management of hepatitis C virus (HCV) coinfection in Indonesia has become an emerging issue due to improved life expectancy of HIV patients since wide acceptance of free antiretroviral program by the government. Prevention of HCV transmission is an important part of management of HCV infection. Various factors related with transmission of HCV among sexual partners of patients with HIV/HCV coinfection were not previously investigated in Indonesia. Thus, the research will be conducted under purpose to identify factors related with HCV prevalence among sexual partners of patients with HIV/HCV coinfection.

Objective
To evaluate the prevalence of HCV infection and factors related with HCV prevalence among sexual partners of HIV/HCV coinfected patients.

Methods
It was a cross sectional study among sexual partners of HIV/HCVcoinfected patients in outpatient clinic Pokdisus Ciptomangunkusumo Hospital Jakarta. Evaluated risk factors are IDUs, blood transfusion, HIV status, condom use, numbers of sexual contacts, numbers of sexual partners, types of sexual contacts, and CD4+ count of HIV/HCV coinfected patients. Data was collected by structured interviews for each couple. Blood samples were taken for examination of anti HCV and anti HIV. Statistical analysis were performed using chi square or Fisher test and logistic regression with Cl 95%.

Result
During May August 2008, 119 eligible subjects participated in this study. The median age was 26 years (range 19 39 years), 95.8% were female. HCV seroprevalence was 10.1%. There was statistically significant difference in HCV prevalence between subjects with history of non vaginal sexual contacts and those without them (PR 5.61; CI 95% 1.20 26.29; p = 0,047). Sub-analysis of non IDU groups, we found that HCV prevalence were higher either in subjects with anti HIV positive or in subjects with history of non vaginal sexual contact; even though in multiple logistic regression analysis showed that only history of non vaginal sexual contacts related with HCV prevalence (adjusted PR 8.051; CI 95% 1.215 53.353)

Conclusion
Hepatitis C virus prevalence was 10.1% among sexual partners of HIV/HCV coinfected patients. Non vaginal sexual contacts and anti HIV positive Ams will increase acquired HCV infection risk up to 8 times. Further studies were needed to evaluate hepatitis C virus sexual transmission among sexual partners of HIV/HCV coinfected patients.

Key word. hepatitis C virus, transmission, sexualpartners,HIV/HCV coinfection

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